CASY technology is based on the electrical detection of the cells when they pass through a measuring pore. Cells with an intact cell membrane exclude the electrical current and generate a signal that depends on the volume of the cell (Electrical Current Exclusion, ECE). Dead cells with a damaged cell membrane can no longer exclude the current and are recorded with the volume of their cell nucleus. The “pulse area analysis” developed especially for CASY technology is a digital signal evaluation with one million measuring points per second. The high resolution achieved ensures that vital cells are recorded separately from dead cells and that the CASY covers a very large measuring range. This means that all objects from cell debris to dead and vital cells to large cell clusters are recorded simultaneously with a single measurement.